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Cayman TM-N1324
List Price $62.00 Your Price $62.00
Cayman TM-N1324 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-37208-1
MFG.PART: 37208-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
TM-N1324 is an agonist of g protein-coupled receptor 39 (GPR39).1 It is selective for GPR39 over a panel of 165 GPCRs, including the growth hormone (GH) secretagogue receptor (GHS-R) and motilin receptor, at 1 µM. TM-N1324 induces inositol phosphate accumulation in HEK293 cells expressing human GPR39 (EC50s = 2 and 201 nM in the presence and absence of zinc, respectively) and cAMP accumulation in COS-7 cells expressing human GPR39 (EC50 = 17 nM in the presence of zinc). It decreases ghrelin secretion and increases somatostatin secretion in isolated mouse gastric mucosa cells when used at a concentration of 1 µM. TM-N1324 (30 mg/kg) decreases food intake during the dark period and body weight in a mouse model of high-fat diet-induced obesity.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-(2-chloro-4-
CAS Number
1144477-35-9
Synonyms
- Compound 1324
- Cpd1324
Molecular Formula
C18H13ClFN7O
Formula Weight
397.8
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
- Ethanol: soluble
SMILES
O=C1NC2=C(C(C1)C3=CC=C(C=C3Cl)F)C(C)=NN2C4=NC=NC5=C4NC=N5
InChi Code
InChI=1S/C18H13ClFN7O/c1-8-14-11(10-3-2-9(20)4-12(10)19)5-13(28)25-17(14)27(26-8)18-15-16(22-6-21-15)23-7-24-18/h2-4,6-7,11H,5H2,1H3,(H,25,28)(H,21,22,23,24)
InChi Key
CYQNVXRIWKKWQG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37208-1 |
|---|---|
| Supplier Part Number | 37208-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1144477-35-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |