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Cayman ETP-46321
List Price $757.00 Your Price $757.00
Cayman ETP-46321 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-37330-25
MFG.PART: 37330-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ETP-46321 is an inhibitor of PI3K p110α and p110δ (apparent Kis = 2.3 and 14.2 nM, respectively).1 It is selective for PI3K p110α and p110δ over p110β and p110γ (apparent Kis = 170 and 179 nM, respectively), as well as a panel of 288 kinases at 1 µM. ETP-46321 inhibits Akt phosphorylation in U2OS cells (IC50 = 8.3 nM). In vivo, ETP-43621 (50 mg/kg) reduces tumor volume in a K-RasG12V-driven murine lung tumor model. It also reduces anti-collagen IgG1 and IgG2a production, swelling, and joint rigidity in a mouse model of collagen-induced arthritis.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[2-[[4-
CAS Number
1252594-99-2
Molecular Formula
C20H27N9O3S
Formula Weight
473.6
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
λmax
270 nm
SMILES
O=S(N1CCN(CC1)CC2=CN3C=C(C4=CN=C(N)N=C4)N=C(N5CCOCC5)C3=N2)(C)=O
InChi Code
InChI=1S/C20H27N9O3S/c1-33(30,31)29-4-2-26(3-5-29)12-16-13-28-14-17(15-10-22-20(21)23-11-15)25-19(18(28)24-16)27-6-8-32-9-7-27/h10-11,13-14H,2-9,12H2,1H3,(H2,21,22,23)
InChi Key
OHKDVDMWRKFZRB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37330-25 |
|---|---|
| Supplier Part Number | 37330-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1252594-99-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |