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Cayman Bradykinin (human, mouse, rat, bovine) (acetate)
List Price $234.00 Your Price $234.00
Cayman Bradykinin (human, mouse, rat, bovine) (acetate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-37408-25
MFG.PART: 37408-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Bradykinin is an endogenous vasodilator that is also involved in inflammation.1,2 It is formed from kininogen via cleavage of high molecular weight kininogen (HMWK) by kallikrein or prekallikrein in a Factor XIIa-dependent or -independent manner.3 Bradykinin binds to the bradykinin B2 receptor (IC50 = 0.54 nM in COS-7 cells expressing the human receptor) and acts as an agonist but does not bind the bradykinin B1 receptor (Ki = >10,000 nM in HEK293 cells expressing the human receptor).4,5 It stimulates arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO Cells expressing the human bradykinin B2 receptor (EC50 = 0.7 nM).4 Bradykinin (100 nM) induces relaxation of isolated porcine coronary arterial rings precontracted with acetylcholine (ACh; Item No. 23829) or phorbol 12,13-dibutyrate (PDBu; Item No. 27785).1 It induces hyperalgesia in mice when administered at a dose of 1 µg/paw, an effect that can be reversed by the bradykinin B2 antagonist icatibant (HOE 140; Item No. 24083).2 Plasma levels of bradykinin are increased in patients during an acute attack of angioedema.6
WARNING This product is not for human or veterinary use.
Technical Information
CAS Number
6846-03-3
Synonyms
- Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
- BK
- RPPGFSPFR-OH
Molecular Formula
C50H73N15O11 • XC2H4O2
Formula Weight
1060.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMSO: 12 mg/mL
- Ethanol: 10 mg/mL
- PBS (pH 7.2): 2 mg/mL
SMILES
CC(O)=O.O=C(N(CCC1)[C@@H]1C(NCC(N[C@H](C(N[C@@H](CO)C(N(CCC2)[C@@H]2C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)[C@H](CCC5)N5C([C@@H](N)CCCNC(N)=N)=O
InChi Code
InChI=1S/C50H73N15O11.C2H4O2/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55;1-2(3)4/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57);1H3,(H,3,4)/t32-,33-,34-,35-,36-,37-,38-,39-;/m0./s1
InChi Key
VIGBULRGBBKXHS-MIEKKPBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37408-25 |
|---|---|
| Supplier Part Number | 37408-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 6846-03-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |