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Cayman IMR-1A
List Price
$928.00
Your Price
$928.00
Cayman IMR-1A - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-37432-100
MFG.PART:
37432-100
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Item No. 27920).1 It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and CFB1, suppressor of Hairless, Lag-1 (CSL) transcription factor. IMR-1A increases multiciliation in primary choroid plexus cancer cells when used at a concentration of 25 µM.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[2-methoxy-
CAS Number
331862-41-0
Molecular Formula
C13H11NO5S2
Formula Weight
325.4
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMSO: 25 mg/mL
λmax
393 nm
SMILES
O=C(COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC)O
InChi Code
InChI=1S/C13H11NO5S2/c1-18-9-4-7(2-3-8(9)19-6-11(15)16)5-10-12(17)14-13(20)21-10/h2-5H,6H2,1H3,(H,15,16)(H,14,17,20)
InChi Key
DVBJNSKWHSGTDK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37432-100 |
|---|---|
| Supplier Part Number | 37432-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 331862-41-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |