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Cayman FL-411
Product Description
Urocortin is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin II (Item Nos. | ), urocortin III (Item Nos. | | ), frog sauvagine, and piscine urotensin I. Human urocortin shares 95% sequence homology with rat urocortin (Item No. ). Urocortin binds to type 1 and 2 CRF receptors as well as CRF binding protein (CRF-BP) with Ki values of 0.41, 1.8, 1.5, and 0.22 nM for human CRF1, rat CRF2α, mouse CRF2β, and human CRF-BP, respectively. It induces cAMP production in CHO cells expressing human CRF1, rat CRF2α, and mouse CRF2β receptors (EC50s = 0.22, 0.32, and 0.13 nM, respectively). Urocortin induces secretion of adrenocorticotropic hormone (ACTH) by rat anterior pituitary cells in a concentration-dependent manner, an effect that can be inhibited by human CRF-BP. It inhibits migration and proliferation of human vascular smooth muscle cells (VSMCs) and reduces LDL-induced foam cell formation in vitro. In vivo, urocortin slows development of aortic atherosclerotic lesions in Apoe-/- mice. Urocortin also decreases food intake in food-deprived and non-deprived rats as well as water intake in water-deprived rats in a dose-dependent manner.
WARNING This product is not for human or veterinary use.
Technical Information
- Formic Acid: 1 mg/ml
Shipping & Storage Information
| SKU | CAYM-37547-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 37547-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |