Cayman FL-411

Name: Cayman FL-411
SKU: CAYM-37547-1
Price: 37.00 USD

List Price $37.00 Your Price $37.00

Cayman FL-411 - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-37547-1

MFG.PART: 37547-1

UNSPSC: 12352200

Manufacturer: Cayman

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Description

Product Description

Urocortin is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin II (Item Nos. | ), urocortin III (Item Nos. | | ), frog sauvagine, and piscine urotensin I. Human urocortin shares 95% sequence homology with rat urocortin (Item No. ). Urocortin binds to type 1 and 2 CRF receptors as well as CRF binding protein (CRF-BP) with K_i values of 0.41, 1.8, 1.5, and 0.22 nM for human CRF₁, rat CRF_2α, mouse CRF_2β, and human CRF-BP, respectively. It induces cAMP production in CHO cells expressing human CRF₁, rat CRF_2α, and mouse CRF_2β receptors (EC₅₀s = 0.22, 0.32, and 0.13 nM, respectively). Urocortin induces secretion of adrenocorticotropic hormone (ACTH) by rat anterior pituitary cells in a concentration-dependent manner, an effect that can be inhibited by human CRF-BP. It inhibits migration and proliferation of human vascular smooth muscle cells (VSMCs) and reduces LDL-induced foam cell formation in vitro. In vivo, urocortin slows development of aortic atherosclerotic lesions in Apoe^-/- mice. Urocortin also decreases food intake in food-deprived and non-deprived rats as well as water intake in water-deprived rats in a dose-dependent manner.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

L-α-aspartyl-L-asparaginyl-L-prolyl-L-seryl-L-leucyl-L-seryl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-threonyl-L-leucyl-L-leucyl-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-glutaminyl-L-seryl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-phenylalanyl-L-α-aspartyl-L-seryl-L-valinamide, trifluoroacetate salt

Molecular Formula

C₂₀₄H₃₃₇N₆₃O₆₄ • XCF₃COOH

Formula Weight

4696.2

Purity

≥95%

Formulation

A lyophilized powder

Solubility

Formic Acid: 1 mg/ml

SMILES

NC([C@H](C(C)C)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@@H]1CCCN1C([C@H](CC(N)=O)NC([C@@H](N[H])CC(O)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F

InChi Code

InChI=1S/C204H337N63O64.C2HF3O2/c1-28-100(20)154(262-191(323)140(90-271)257-180(312)127(75-96(12)13)247-189(321)138(88-269)259-192(324)141-52-42-70-267(141)199(331)136(83-146(210)279)255-163(295)111(205)81-150(286)287)193(325)254-135(85-152(290)291)185(317)246-129(77-98(16)17)187(319)266-159(107(27)274)198(330)253-131(79-109-45-35-32-36-46-109)181(313)248-132(80-110-86-222-91-228-110)183(315)245-126(74-95(10)11)178(310)243-124(72-93(6)7)176(308)235-116(51-41-69-227-204(220)221)174(306)265-158(106(26)273)197(329)251-128(76-97(14)15)179(311)244-125(73-94(8)9)177(309)239-122(58-64-149(284)285)170(302)242-123(71-92(4)5)175(307)230-104(24)161(293)231-114(49-39-67-225-202(216)217)173(305)264-157(105(25)272)196(328)241-119(55-61-144(208)277)171(303)256-137(87-268)188(320)240-117(53-59-142(206)275)166(298)234-113(48-38-66-224-201(214)215)165(297)238-121(57-63-148(282)283)168(300)233-112(47-37-65-223-200(212)213)164(296)229-103(23)162(294)232-120(56-62-147(280)281)167(299)237-118(54-60-143(207)276)169(301)249-133(82-145(209)278)184(316)236-115(50-40-68-226-203(218)219)172(304)261-156(102(22)30-3)195(327)263-155(101(21)29-2)194(326)252-130(78-108-43-33-31-34-44-108)182(314)250-134(84-151(288)289)186(318)258-139(89-270)190(322)260-153(99(18)19)160(211)292;3-2(4,5)1(6)7/h31-36,43-46,86,91-107,111-141,153-159,268-274H,28-30,37-42,47-85,87-90,205H2,1-27H3,(H2,206,275)(H2,207,276)(H2,208,277)(H2,209,278)(H2,210,279)(H2,211,292)(H,222,228)(H,229,296)(H,230,307)(H,231,293)(H,232,294)(H,233,300)(H,234,298)(H,235,308)(H,236,316)(H,237,299)(H,238,297)(H,239,309)(H,240,320)(H,241,328)(H,242,302)(H,243,310)(H,244,311)(H,245,315)(H,246,317)(H,247,321)(H,248,313)(H,249,301)(H,250,314)(H,251,329)(H,252,326)(H,253,330)(H,254,325)(H,255,295)(H,256,303)(H,257,312)(H,258,318)(H,259,324)(H,260,322)(H,261,304)(H,262,323)(H,263,327)(H,264,305)(H,265,306)(H,266,319)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H4,212,213,223)(H4,214,215,224)(H4,216,217,225)(H4,218,219,226)(H4,2

InChi Key

MSZWJDXFFRAJNC-BELMYTGDSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-37547-1
Featured	No
Supplier Part Number	37547-1
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
Temperature	-20
Refrigerated-Frozen	Refrigerated
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	2
Hazardous	N
Energy Star	No
Green	No
ACT Ecolabel	No
Controlled	N

Provide Content Correction

NETA PART NO.	Quantity

Cayman FL-411

Product Description

Technical Information

Shipping & Storage Information

Product Title