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Cayman Td52; 10 Mg; 1798328-24-1; ≥98%
List Price
$163.00
Your Price
$163.00
Cayman Td52; 10 Mg; 1798328-24-1; ≥98% - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-37744-10
MFG.PART:
37744-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TD52 is a derivative of the EGFR tyrosine kinase inhibitor erlotinib (Item Nos. 10483 | 35517).1 It decreases the viability of HA22T, Hep3B, PLC/PRF/5, and SK-HEP-1 hepatocellular carcinoma cells (IC50s = 0.9, 0.9, 0.8, and 1.2 µM, respectively). TD52 induces apoptosis in a variety of cancer cells, including HA22T and Hep3B hepatocellular carcinoma and HCC1937 and MDA-MB-231 triple-negative breast cancer cells in a concentration-dependent manner.1,2 TD52 (10 mg/kg per day) increases intratumoral protein phosphatase 2A (PP2A) activity, reduces intratumoral cancerous inhibitor of PP2A (CIP2A) and phosphorylated Akt levels, and reduces tumor growth in a PLC/PRF/5 mouse xenograft model.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N2,N3-bis(3-ethynylphenyl)-2,3-quinoxalinediamine
CAS Number
1798328-24-1
Molecular Formula
C24H16N4
Formula Weight
360.4
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/ml
- DMSO: 5 mg/ml
λmax
237, 246, 277, 366 nm
SMILES
C#CC1=CC=CC(NC2=NC3=C(N=C2NC4=CC(C#C)=CC=C4)C=CC=C3)=C1
InChi Code
InChI=1S/C24H16N4/c1-3-17-9-7-11-19(15-17)25-23-24(26-20-12-8-10-18(4-2)16-20)28-22-14-6-5-13-21(22)27-23/h1-2,5-16H,(H,25,27)(H,26,28)
InChi Key
SCUPZFSEJFWQIS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37744-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 37744-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1798328-24-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |