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Cayman AZD 5305
List Price $143.00 Your Price $143.00
Cayman AZD 5305 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-37769-5
MFG.PART: 37769-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AZD 5305 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 0.003 µM).1 It is selective for PARP1 over PARP2, PARP3, PARP5a, and PARP6 (IC50s = 1.4, 3.4, >89, and 26 µM, respectively). AZD 5305 inhibits the proliferation of BRCA2-/- DLD-1 colorectal cancer cells (IC50 = 0.002 µM). It induces tumor regression in a patient-derived xenograft (PDX) mouse model of BRCA1 mutant triple-negative breast cancer (TNBC) when administered at doses ranging from 0.3 to 10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[4-[(7-
CAS Number
2589531-76-8
Molecular Formula
C22H26N6O2
Formula Weight
406.5
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.5 mg/mL
- DMSO: 0.1 mg/mL
λmax
222, 330 nm
SMILES
O=C(C1=NC=C(N2CCN(CC2)CC3=CC4=C(C=C(CC)C(N4)=O)N=C3)C=C1)NC
InChi Code
InChI=1S/C22H26N6O2/c1-3-16-11-19-20(26-21(16)29)10-15(12-24-19)14-27-6-8-28(9-7-27)17-4-5-18(25-13-17)22(30)23-2/h4-5,10-13H,3,6-9,14H2,1-2H3,(H,23,30)(H,26,29)
InChi Key
WQAVGRAETZEADU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37769-5 |
|---|---|
| Supplier Part Number | 37769-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2589531-76-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |