Cayman Std1t; 25 Mg; 893075-58-6; ≥98%

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus. It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells. It also inhibits cell proliferation in HER2⁺ breast cancer cell lines (IC₅₀s = 12.9-61.5 µM, respectively) and decreases the number of invasive cells in vitro.^, When combined with lapatinib (Item No. ), tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone. Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC₅₀ = 9.31 µM). It also inhibits β1 integrin activation leading to a loss of cellular adhesion.

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