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Cayman AVE-0991
List Price
$765.00
Your Price
$765.00
Cayman AVE-0991 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-37837-25
MFG.PART:
37837-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AVE-0991 is an agonist of the Mas receptor, also known as the angiotensin (1-7) receptor.1 It binds to the Mas receptor in bovine aortic endothelial cell membranes and COS cells (IC50s = 21 and 47.5 nM, respectively).2,1 It reduces urinary volume in water-loaded mice, an effect that can be blocked by the angiotensin (1-7) antagonist A-779 (Item No. 23396) and is reduced in Mas knockout mice.1 Dietary administration of AVE-0991 (0.58 µmol/kg per day) inhibits perivascular inflammation and increases plaque stability in an ApoE-/- mouse model of atherosclerosis.3 It also inhibits the formation of abdominal aortic aneurysm induced by angiotensin II in ApoE-/- mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(ethyl
CAS Number
304462-19-9
Molecular Formula
C29H32N4O5S2
Formula Weight
580.7
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: Soluble
λmax
230, 275, 305 nm
SMILES
O=CC1=C(OC)N=C(N1CC2=CC=C(C3=C(S(NC(NCC)=O)(=O)=O)SC(CC(C)C)=C3)C=C2)C4=CC=CC=C4
InChi Code
InChI=1S/C29H32N4O5S2/c1-5-30-29(35)32-40(36,37)28-24(16-23(39-28)15-19(2)3)21-13-11-20(12-14-21)17-33-25(18-34)27(38-4)31-26(33)22-9-7-6-8-10-22/h6-14,16,18-19H,5,15,17H2,1-4H3,(H2,30,32,35)
InChi Key
QTOZBSNPDCWHPV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37837-25 |
|---|---|
| Supplier Part Number | 37837-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 304462-19-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |