Cayman LAMP-1/CD107a Rabbit Monoclonal Antibody (Clone 107)

Lysosome-associated membrane protein 1 (LAMP-1), also known as CD107a, is an abundant lysosomal integral membrane glycoprotein.¹ It is composed of a signal peptide, two LAMP-like domains that are separated by a proline-rich hinge region, a transmembrane domain, and a C-terminal tail that contains a YXXI tyrosine-based motif, which is required for targeting of LAMP-1 to the lysosome.^1,2 LAMP-1 is ubiquitously expressed and localizes to lysosomes, endosomes, and the plasma membrane.^1,2 It is involved in human peripheral blood mononuclear cells (PBMC) adhesion to vascular endothelium, natural killer (NK) cell degranulation, virus entry, and cancer progression and metastasis.^3,4,5,6 Homozygous knockout of Lamp1 prevents Lassa virus infection in mice.⁵ Pulmonary protein levels of LAMP-1 are increased in patients with chronic obstructive pulmonary disease (COPD), and increased LAMP-1 lung levels positively correlate with smoking history and negatively correlate with lung function.⁷ Cayman’s LAMP-1/CD107a Rabbit Monoclonal Antibody (Clone 107) can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), immunofluorescence (IF), immunohistochemistry paraffin (IHC-P), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes LAMP-1 at 120 kDa from human samples.

WARNING This product is not for human or veterinary use.