Cayman CD8a Polyclonal Antibody

The CD8 α-chain (CD8a) is a transmembrane glycoprotein that exists as a homodimer, CD8αα, or heterodimer with the CD8 β-chain (CD8b), CD8αβ, to form the T cell receptor (TCR) co-receptor CD8.^1,2 CD8a is composed of an extracellular immunoglobulin variable-like (IgV) domain, which interacts with MHC class I molecules, a transmembrane domain, and a cytoplasmic tail that associates with the tyrosine kinase p56^Ick and mediates signal transduction.^1,3,2 CD8αβ is expressed by cytotoxic T lymphocytes (CTLs), where it acts as a TCR co-receptor by enhancing T cell signaling and activation upon binding to antigen-displaying MHC class I molecules.^4,2 CD8αα is expressed by CTLs and intestinal epithelial lymphocytes, as well as γδ T, natural killer (NK), and dendritic cells, where it acts as a positive or negative regulator of cell activation in a cell-dependent manner. Cd8a^-/- mice infected with M. tuberculosis exhibit reduced survival.⁵ Caymans CD8a Polyclonal Antibody can be used for ELISA, immunocytochemistry (ICC), immunofluorescence (IF), and immunohistochemistry (IHC; paraffin) applications.

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