Cayman Histone H4 (human, recombinant; His-tagged)

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin.¹ Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications (PTMs), such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription.^1,2 Histone H4 PTMs function as epigenetic regulators of transcription by affecting chromatin structure and enhancing transcription factor binding, as well as play a key role in the maintenance of genomic integrity.^3,4 Levels of histone H4 are increased in the inferior and middle temporal gyrus in postmortem brains from patients with Alzheimer’s disease.⁵

WARNING This product is not for human or veterinary use.