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Cayman GPX4 24
List Price $74.00 Your Price $74.00
Cayman GPX4 24 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-38428-1
MFG.PART: 38428-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GPX4 24 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of (1S,3R)-RSL3 (Item No. 19288).1 It covalently binds to GPX4 in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. GPX4 24 induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells (EC50 = 0.16 µM). It increases kidney and plasma malondialdehyde (MDA) levels in mice when administered at a dose of 200 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
methyl (1S,3R)-2-(2-
Synonyms
- Glutathione Peroxidase 4 24
- PHGPx 24
- Phospholipid Hydroperoxide Glutathione Peroxidase 24
Molecular Formula
C22H21ClN2O5S
Formula Weight
460.9
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 20 mg/mL
λmax
222 nm
SMILES
ClCC(N1[C@H](CC(C2=CC=CC=C2N3)=C3[C@@H]1C4=CC=C(C=C4)S(C)(=O)=O)C(OC)=O)=O
InChi Code
InChI=1S/C22H21ClN2O5S/c1-30-22(27)18-11-16-15-5-3-4-6-17(15)24-20(16)21(25(18)19(26)12-23)13-7-9-14(10-8-13)31(2,28)29/h3-10,18,21,24H,11-12H2,1-2H3/t18-,21+/m1/s1
InChi Key
GONRCSSWFFDKDJ-NQIIRXRSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 3 years
| SKU | CAYM-38428-1 |
|---|---|
| Supplier Part Number | 38428-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2920221-53-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |