Cayman 2-Iminobiotin (hydrobromide)

2-Iminobiotin is a guanidine-modified derivative of the carboxylase coenzyme biotin (Item No. 22582) and an inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; K_is = 21.8 and 37.5 µM for the mouse and rat enzymes, respectively).¹ It has been used to label and selectively retrieve sialoglycoproteins from erythrocyte ghosts.² 2-Iminobiotin (0.2 mg/kg every four hours) prevents hypoxia-ischemia-induced decreases in brain phosphocreatine and ATP levels and increases in edema in the parietal cortex and striatum, as well as reduces apoptosis in the parietal- and temporal cortex and striatum, in piglets.³ It increases survival of, and decreases electrographic seizures in, hypoxia-ischemia-injured piglets when administered at doses of 0.2 and 1 mg/kg every four hours.⁴ Lipid nanoparticles (LNPs) containing 2-iminobiotin conjugated to poly-L-lysine have been used to improve LNP tumor targeting, uptake, and retention compared with LNPs containing biotin conjugated to poly-L-lysine in rats.⁵

WARNING This product is not for human or veterinary use.