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Cayman C14-4
List Price $460.00 Your Price $460.00
Cayman C14-4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-38942-10
MFG.PART: 38942-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
C14-4 is an ionizable cationic lipid (pKa = 6.5).1,2 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing C14-4 and encapsulating mRNA encoding chimeric antigen receptor (CAR) induce CAR expression in primary human T cells ex vivo to the same level as expression induced via electroporation, but with reduced cytotoxicity, and induce cytotoxicity in Nalm-6 acute lymphoblastic leukemia (ALL) cells in vitro.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,1′-[[2-[2-[4-
CAS Number
2639634-80-1
Synonyms
- C14-494
- Lipid B4
Molecular Formula
C84H173N5O7
Formula Weight
1365.3
Purity
≥95% (mixture of isomers)
Formulation(Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
- Ethanol: 10 mg/mL
SMILES
CCCCCCCCCCCCC(O)CN(CC(O)CCCCCCCCCCCC)CCOCCN(CCN1CCN(CCOCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC1)CC(O)CCCCCCCCCCCC
InChi Code
InChI=1S/C84H173N5O7/c1-6-11-16-21-26-31-36-41-46-51-56-80(90)75-87(68-72-96-74-70-89(78-83(93)59-54-49-44-39-34-29-24-19-14-9-4)79-84(94)60-55-50-45-40-35-30-25-20-15-10-5)66-65-85-61-63-86(64-62-85)67-71-95-73-69-88(76-81(91)57-52-47-42-37-32-27-22-17-12-7-2)77-82(92)58-53-48-43-38-33-28-23-18-13-8-3/h80-84,90-94H,6-79H2,1-5H3
InChi Key
OQALBVGFAKJDAR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 1 year
| SKU | CAYM-38942-10 |
|---|---|
| Supplier Part Number | 38942-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 2639634-80-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |