Cayman 13(S)-HpODE

13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,^1,2 and by 15-LO in mammals.³ In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase.⁴ In mammalian tissues, 13(S)-HpODE is generally reduced to 13(S)-HODE (Catalog No. 38610), a compound which exhibits many biological activities.³ A direct action for 13(S)-HpODE has been demonstrated in Syrian hamster embryo cells where it stimulates EGF-dependent mitogenesis and up-regulation of EGF-dependent tyrosine phosphorylation.⁵ Membrane-esterified 13(S)-HpODE has been identified in human atherosclerotic plaques.⁶

WARNING This product is not for human or veterinary use.