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Cayman (±)11(12)-EET
List Price $195.00 Your Price $195.00
Cayman (±)11(12)-EET - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-50511-100
MFG.PART: 50511-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Item No. ) by cytochrome P450 enzymes.,, A higher proportion of 11R(12S)-EET (Item No. ) is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11S(12R)-EET (Item No. ) 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET (Item No. ), to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-PS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 µg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
rel-10-
CAS Number
87173-81-7
Synonyms
- (±)11,12-EpETrE
Molecular Formula
C20H32O3
Formula Weight
320.5
Purity
≥95%
Formulation
A solution in ethanol
Solubility
- DMF: 50 mg/mL
- DMSO: 50 mg/mL
- Ethanol: 50 mg/mL
- PBS pH 7.2: 1 mg/mL
SMILES
CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(=O)O
InChi Code
InChI=1S/C20H32O3/c1-2-3-4-5-9-12-15-18-19(23-18)16-13-10-7-6-8-11-14-17-20(21)22/h6,8-10,12-13,18-19H,2-5,7,11,14-17H2,1H3,(H,21,22)/b8-6-,12-9-,13-10-/t18-,19+/m1/s1
InChi Key
DXOYQVHGIODESM-LZXKBWHHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-50511-100 |
|---|---|
| Supplier Part Number | 50511-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 87173-81-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |