Cayman COX-1 (ovine)

Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities.^, It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney, spleen, liver, and lung and localizes to the endoplasmic reticulum.^, The COX component converts arachidonic acid (Item Nos. | | ) to a hydroperoxyl endoperoxide prostaglandin g₂ (PGG₂; Item No. ) and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH₂ (Item No. ), the precursor of PGs, thromboxanes, and prostacyclins.^, COX-1 is the target of many non-steroidal anti-inflammatory drugs (NSAIDs) and is responsible for the undesirable gastrointestinal and renal side effects, such as ulcer formation and reductions in the glomerular filtration rate, respectively.^, Cayman’s COX-1 (ovine) protein can be used for enzyme activity assays.

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