Cayman COX-2 (human, recombinant)

Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins.^, The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin g₂ (PGG₂; Item No. ), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH₂ (Item No. ). COX-2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has been the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Caymans COX-2 (human, recombinant) contains an N-terminal hexahistidine tag and an alanine substituted for asparagine at position 580 (COX-2^N580A) that prevents glycosylation at position 580 and decreases enzyme degradation in cells.

WARNING This product is not for human or veterinary use.