Cayman Aspirin

Aspirin is a non-steroidal anti-inflammatory drug (NSAID) and a covalent inhibitor of COX-1 and COX-2 (IC₅₀s = 4.45 and 13.88 µM, respectively, for the human enzymes).¹ It is also an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC₅₀ = 750 µM for the ovine enzyme).² Aspirin (6 µg/mL) inhibits epinephrine- and ADP-induced platelet aggregation.³ In vivo, aspirin (30 mg/kg) reduces infarct volume and microglial infiltration in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).⁴ It decreases macrophage infiltration into, increases the number of smooth muscle cells and levels of collagen in, and reduces the area of, atherosclerotic lesions in LDL receptor-deficient mice fed a high-fat diet when administered in the drinking water at 30 mg/L.⁵ Formulations containing aspirin have been used in the treatment of pain, fever, and in stroke prevention.

WARNING This product is not for human or veterinary use.