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Cayman U-0126
List Price $412.00 Your Price $412.00
Cayman U-0126 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-70970-25
MFG.PART: 70970-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively.1 It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells).2 It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,3-
CAS Number
109511-58-2
Molecular Formula
C18H16N6S2
Formula Weight
380.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF: PBS (pH 7.2)(1:2): 0.3 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 0.5 mg/mL
λmax
247, 308 nm
SMILES
N/C(SC1=CC=CC=C1N)=C(C#N)\C(C#N)=C(N)\SC2=C(N)C=CC=C2
InChi Code
InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChi Key
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-70970-25 |
|---|---|
| Supplier Part Number | 70970-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 109511-58-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |