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Cayman Spla2 Dtnb; Size- 1 Ea
List Price
$10.00
Your Price
$10.00
Cayman Spla2 Dtnb; Size- 1 Ea; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-765012-1
MFG.PART:
765012-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
BMS 470539 is an agonist of melanocortin receptor 1 (MC1R). It induces cAMP accumulation in B16/F10 murine melanoma cells and in CHO cells overexpressing human MC1R (EC50s = 11.6 and 16.8 nM, respectively). It inhibits TNF-α-induced NF-κB activation in vitro in a concentration-dependent manner. In vivo, BMS 470539 inhibits LPS-induced TNF-α production in mice (ED50 = 10 μmol/kg, s.c.). It reduces LPS-induced leukocyte infiltration and paw swelling in mouse models of lung inflammation and delayed-type hypersensitivity, respectively. BMS 470539 decreases retinal damage in a mouse model of streptozotocin-induced diabetic retinopathy. It also increases striatal dopamine levels and decreases the number of striatal α-synuclein aggregates in a mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[1-(3-methyl-
CAS Number
2341796-82-3
Molecular Formula
C32H41N5O4 • 2HCl
Formula Weight
632.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 20 mg/ml
- PBS (pH 7.2): 5 mg/ml
λmax
273 nm
SMILES
O=C([C@@H](CC1=CC=C(OC)C=C1)NC([C@@H](N)CC2=CN=CN2C)=O)N3CCC(C4=CC=CC=C4)(C(CCC)=O)CC3.Cl.Cl
InChi Code
InChI=1S/C32H41N5O4.2ClH/c1-4-8-29(38)32(24-9-6-5-7-10-24)15-17-37(18-16-32)31(40)28(19-23-11-13-26(41-3)14-12-23)35-30(39)27(33)20-25-21-34-22-36(25)2;;/h5-7,9-14,21-22,27-28H,4,8,15-20,33H2,1-3H3,(H,35,39);2*1H/t27-,28+;;/m0../s1
InChi Key
DUAOBJHRUKFKIH-YDVFRNEYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-765012-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 765012-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |