Cayman Dihydrorhodamine 123; Purity- Greater Than Or Equal To 98%

Zosuquidar is a modulator of P-glycoprotein (P-gp; K_i = 59 nM). It restores the sensitivity of P-gp-expressing cancer cells to vinblastine (Item No. ), doxorubicin (Item No. ), etoposide (Item No. ), and paclitaxel (Item No. ) when used at 0.1 µM. It less potently inhibits cytochrome P450 (CYP) isoforms CYP3A, CYP2D6, and CYP2C9 (K_is = 3.8, 25, and 12 µM, respectively). Zosuquidar does not modulate multidrug resistance-associated protein 1 (MRP-1). Zosuquidar significantly enhances the efficacy of chemotherapeutics in mice implanted with P-gp-expressing tumors. Through its effects on P-gp, zosuquidar enhances the distribution of P-gp substrates through the blood-brain barrier into the brain.^,

WARNING This product is not for human or veterinary use.