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Cayman 8-Hydroxy-2-Deoxyguanosine; Purity- Greater Than Or Equal
List Price
$796.00
Your Price
$796.00
Cayman 8-Hydroxy-2-Deoxyguanosine; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-89320-25
MFG.PART:
89320-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Voacangine is an indole alkaloid that has been found in T. citrifolia, V. africana, V. obtusa, and T. iboga with diverse biological activities., It inhibits the growth of M. tuberculosis, M. avium, and M. kansasii with MIC values of 50, >200, and 100 μg/mL, respectively. Voacangine (0.01-100 μM) dose-dependently reduces membrane currents in HEK293 cells expressing the hERG potassium channel and displaces the hERG ligand dofetilide (Item No. ) with a Ki value of 3.9 μM. Voacangine suppresses agonist-induced activation of transient receptor potential (TRP) channels with IC50 values of 50 and 9 μM for activation induced by the TRPV1 agonist capsaicin (Item No. ) and the TRPM8 agonist menthol, respectively. It also activates TRPA1 channels and stimulates calcium influx (IC50 = 8 μM in HEK293 cells expressing TRPA1), an effect that is blocked by the TRPA1 blocker HC-030031 (Item No. ). In vivo, voacangine (2 and 4 μg per egg) inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
12-methoxy-
CAS Number
510-22-5
Synonyms
- 10-methoxy Coronaridine
Molecular Formula
C22H28N2O3
Formula Weight
368.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 16 mg/ml
- DMSO: 16 mg/ml
- DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml
λmax
226, 288 nm
SMILES
[H][C@]12[C@@H](CC)C[C@]3([H])C[C@@]1(C(OC)=O)C4=C(C(C=C(OC)C=C5)=C5N4)CC[N@]2C3
InChi Code
InChI=1S/C22H28N2O3/c1-4-14-9-13-11-22(21(25)27-3)19-16(7-8-24(12-13)20(14)22)17-10-15(26-2)5-6-18(17)23-19/h5-6,10,13-14,20,23H,4,7-9,11-12H2,1-3H3/t13-,14+,20+,22-/m1/s1
InChi Key
MMAYTCMMKJYIAM-PHKAQXKASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-89320-25 |
|---|---|
| Featured | No |
| Supplier Part Number | 89320-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | 22 |
| Refrigerated-Frozen | Ambient |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 88847-89-6 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |