Cayman 8-Hydroxy-2-Deoxyguanosine; Purity- Greater Than Or Equal

Perphenazine is a typical antipsychotic. It binds to dopamine D₂, α_1A-, α_2A-, α_2B-, and α_2C-adrenergic, M₃ muscarinic, and histamine H₁ receptors (K_is = 1.4, 10, 1,848, 104.9, 85.2, 810.5 and 8 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT_1A, 5-HT_2A, 5-HT_2C, 5-HT₆, and 5-HT₇ (K_is = 421, 5.6, 132, 17, and 23 nM, respectively). Perphenazine (1, 5, and 10 mg/kg) enhances morphine-induced analgesia in the tail-flick and hot plate tests in rats. It reduces cannibalism in female mice when administered at doses of 2 and 4 mg/kg. Formulations containing perphenazine have been used in the treatment of schizophrenia and psychosis.

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