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Cayman Hydroxy Linoleins; Purity- Greater Than Or Equal To 98% (A
List Price
$216.00
Your Price
$216.00
Cayman Hydroxy Linoleins; Purity- Greater Than Or Equal To 98% (A Mixture Of 132 Isomers); Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-89420-5
MFG.PART:
89420-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Platelet-type 12-lipoxygenase (12-LO; Item No. ) catalyzes the formation of 12-HpETE (Item No. ) from arachidonic acid (Item No. ). It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function. ML-355 is a selective inhibitor of 12-LO with an IC50 value of 0.34 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM) and no inhibition of COX-1 and -2. In cell-based assays, ML-355 has been shown to decrease calcium mobilization and thrombin receptor PAR4-induced platelet aggregation in patient-derived human platelets and to significantly inhibit arachidonic acid and calcium- ionophore-induced 12-HpETE synthesis in mouse BTC3 cells and human islets.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-2-benzothiazolyl-
CAS Number
1532593-30-8
Molecular Formula
C21H19N3O4S2
Formula Weight
441.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 1 mg/ml
- DMSO: 1 mg/ml
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
300 nm
SMILES
COC1=C(O)C(CNC2=CC=C(S(NC3=NC4=C(C=CC=C4)S3)(=O)=O)C=C2)=CC=C1
InChi Code
InChI=1S/C21H19N3O4S2/c1-28-18-7-4-5-14(20(18)25)13-22-15-9-11-16(12-10-15)30(26,27)24-21-23-17-6-2-3-8-19(17)29-21/h2-12,22,25H,13H2,1H3,(H,23,24)
InChi Key
OWHBVKBNNRYMIN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-89420-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 89420-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |