Cayman MJ33 (lithium salt)

Peroxiredoxin-6 (Prdx6) is a bifunctional enzyme that has both non-selenium glutathione peroxidase (GPX) and phospholipase A₂ (PLA₂) activities.¹ Its PLA₂ activity is calcium-independent, functions optimally in acidic (pH = 4) conditions, and facilitates the intracellular processing of surfactant lipids, including dipalmitoylphosphatidylcholine (DPPC).^1,2,3 MJ33 is a selective, reversible inhibitor of the acidic, calcium-independent (ai)PLA₂ activity of Prdx6, with optimal inhibition achieved at an MJ33 concentration of 3 mol%.^4,5,6 It blocks the degradation of DPPC in both whole lung and isolated alveolar type II epithelial cells.² MJ33 has been used to examine the role of Prdx6 PLA₂ activity in the activation of type 2 NADPH oxidase and in the regulation of Prdx6 PLA₂ activity by phosphorylation.^7,8

WARNING This product is not for human or veterinary use.