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Cayman Arachidoyl Glycine; Purity- Greater Than Or Equal To 98%;
List Price
$41.00
Your Price
$41.00
Cayman Arachidoyl Glycine; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-9000325-5
MFG.PART:
9000325-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively). It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1; Item No. ) in vitro. Zibotentan reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2, mediators of cell invasion and angiogenesis, in HEY cells. In vivo, zibotentan (10-50 mg/kg per day) reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner. Formulations containing zibotentan are under clinical investigation for the treatment of ovarian and castration-resistant prostate cancers.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(3-methoxy-
CAS Number
186497-07-4
Synonyms
- ZD 4054
Molecular Formula
C19H16N6O4S
Formula Weight
424.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml
λmax
265 nm
SMILES
CC1=NC(OC)=C(NS(C2=CC=CN=C2C3=CC=C(C4=NN=CO4)C=C3)(=O)=O)N=C1
InChi Code
InChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChi Key
FJHHZXWJVIEFGJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-9000325-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 9000325-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 617703-96-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |