Cayman (R)-Acenocoumarol; Purity- Greater Than Or Equal To 98%; S

Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM.^,, Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro (IC₅₀ = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (K_d = 2.8 µM).^,, Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARα, lipoprotein lipase, and low-density lipoprotein receptor.

WARNING This product is not for human or veterinary use.