Cayman Pepstatin A

Pepstatin A is a bacteria-derived pentapeptide inhibitor of aspartic proteases.^1,2,3 It inhibits pepsin, cathepsin D, and HIV protease (IC₅₀s = <0.005, <0.04, and 2 µM, respectively).² Pepstatin A is also an inhibitor of renin (IC₅₀s = 0.32 and 15 µM for the porcine and human enzymes, respectively).³ It inhibits HIV replication in infected H9 cells when used at a concentration of 100 µM and inhibits autophagy in PC12 cells.^3,4 Pepstatin A (10 and 50 mg/kg) decreases gastric acid levels and completely prevents pylorus ulceration in pylorus-ligated rats.¹

WARNING This product is not for human or veterinary use.