Cayman Oleoyl Ethanolamide-D4; Purity- Greater Than Or Equal To 9

Oleoyl ethanolamide-d₄ contains four deuterium atoms at the hydroxyethyl 1,1,2, and 2 positions. It is intended for use as an internal standard for the quantification of oleoyl ethanolamide by GC- or LC-mass spectrometry. Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate.¹ It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,² but its biosynthesis is reduced in the intestine of rats following food deprivation.³ OEA is an endogenous, potent agonist for PPARα, exhibiting an EC₅₀ value of 120 nM in a transactivation assay.⁴ Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.^3,4 These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.

WARNING This product is not for human or veterinary use.