Cayman Progesterone 3-Biotin; Purity- Greater Than Or Equal To 98

(±)-4-hydroxy Propranolol is an active metabolite of the β-adrenergic receptor antagonist (±)-propranolol (Item No. ). It is formed from propranolol by the cytochrome P450 (CYP) isoform CYP2D6. (±)-4-hydroxy Propranolol decreases tachycardia and vasodepression induced by the β₁- and β₂-adrenergic receptor agonist isoproterenol (Item No. ) in cats (EC₅₀ = 54 µg/kg). It increases heart rate in rats depleted of catecholamines by the monocarboxylate transporter 1 (MCT1) and MCT2 inhibitor syrosingopine (Item No. ) when administered at doses of 10 and 80 µg/kg. (±)-4-hydroxy Propranolol decreases heart rate, myocardial contractility, and cardiac output in dogs in a dose-dependent manner. It also reduces superoxide-induced lipid peroxidation in isolated rat hepatic microsomes (IC₅₀ = 1.1 µM) and prevents superoxide-induced depletion of glutathione (GSH) levels in bovine aortic endothelial cells (BAECs; EC₅₀ = 1.2 µM).

WARNING This product is not for human or veterinary use.