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Cayman (+)-JQ1 (free acid)
List Price $60.00 Your Price $60.00
Cayman (+)-JQ1 (free acid) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-9002910-1
MFG.PART: 9002910-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
(+)-JQ1 (free acid) is an inhibitor of bromodomain and extra terminal domain (BET) family proteins (Kds = 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively), blocking their interaction with acetylated histones., Enantiomerically pure (+)-JQ1 (Item No. ) binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the (−)-JQ1 (Item No. ) stereoisomer has no appreciable affinity to BET bromodomains. JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.,,,, See the Structural Genomics Consortium (SGC) website for more information.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(6S)-4-(4-ch
CAS Number
202592-23-2
Molecular Formula
C19H17ClN4O2S
Formula Weight
400.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 25 mg/mL
- DMSO:PBS(pH 7.2) (1:4): 0.20 mg/mL
- Ethanol: 15 mg/mL
λmax
254 nm
SMILES
CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(O)=O)=C(S1)N4C3=NN=C4C
InChi Code
InChI=1S/C19H17ClN4O2S/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)21-14(8-15(25)26)18-23-22-11(3)24(18)19/h4-7,14H,8H2,1-3H3,(H,25,26)/t14-/m0/s1
InChi Key
LJOSBOOJFIRCSO-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-9002910-1 |
|---|---|
| Supplier Part Number | 9002910-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 202592-23-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |