Cayman Satratoxin g

Satratoxin g is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.^, It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC₅₀s = 2.2-9.7 ng/mL).^, Intranasal administration of satratoxin g (500 μg/kg) induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice. Satratoxin g induces lethality in 4 week-old male mice (LD₅₀ = 1.23 mg/kg, i.p.).

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