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Cayman Paraxanthine-D6, 3,7-Dihydro-1,7-Di(Methyl-D3)-1h-Purine-2
List Price
$722.00
Your Price
$722.00
Cayman Paraxanthine-D6, 3,7-Dihydro-1,7-Di(Methyl-D3)-1h-Purine-2,6-Dione, 5 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-9003564-5
MFG.PART:
9003564-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine (Item No. 21068) by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine (Item No. 14118).1 It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively).2 In vivo, paraxanthine (30 mg/kg) increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA (N6-cyclopentyladenosine; Item No. 21448) or the adenosine A2 receptor agonist CGS 21680 (Item No. 17126) in rats not habituated to caffeine.3 It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3,7-dihydro-
CAS Number
117490-41-2
Synonyms
- 1,7-Dimethylxanthine-d6
Molecular Formula
C7H2D6N4O2
Formula Weight
186.2
Purity
≥99% deuterated forms (d1-d6); ≤1% d0
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 1 mg/ml
- PBS (pH 7.2): 1 mg/ml
SMILES
O=C1C2=C(N=CN2C([2H])([2H])[2H])NC(N1C([2H])([2H])[2H])=O
InChi Code
InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13)/i1D3,2D3
InChi Key
QUNWUDVFRNGTCO-WFGJKAKNSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-9003564-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 9003564-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 117490-41-2 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |