Cayman 15(R)-Lipoxin A4

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A₄ (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE (Item No. 34710) from arachidonic acid (Item No. 90010).^1,2 15(R)-LXA₄ inhibits LTB₄-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA₄ (Item No. 90410) demonstrating activity in the nM range.^2,3 The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA₄ to regulate leukocyte function.⁴ 15(R)-LXA₄ is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.⁵

WARNING This product is not for human or veterinary use.