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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | WB, IHC, IP, IF | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB10522 |
| Replaces | AB9160 |
| Description | Anti-Neuropilin-2 Antibody |
| Alternate Names |
|
| Background Information | There are two forms of Neuropilin: Neuropilin-1 and Neuropilin-2. These are non–tyrosine kinase receptors that bind to VEGF and semaphorins (SEMA3A, SEMA3B, and SEMA3F) and play an important role in the critical functioning of the nervous system. Neuropilin-2 is expressed in tumor cells, and mature and developing endothelial cells and vascular smooth muscle cells. This expression has been associated with tumor angiogenesis and progression. |
| Product Information | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Unpurified Rabbit Serum containing 0.05% Sodium Azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect Neuropilin-2 using this Anti-Neuropilin-2 Antibody validated for use in WB, IH, IP & IF. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | His-tagged partial recombinant rat Neuropilin-2 protein. |
| Epitope | Unknown |
| Host | Rabbit |
| Specificity | This antibody recognizes Neuropilin-2. |
| Isotype | IgG |
| Species Reactivity |
|
| Species Reactivity Note | Proven to react with mouse. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Unpurified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. SUBUNIT STRUCTURE: Heterodimer with NRP1 Probable. Binds PLXNB1 By similarity. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Found in certain neuronal populations of the CNS and in other non-neuronal tissues including mesenchymal tissue lining in the ribs. DEVELOPMENTAL STAGE: The expression pattern is very dynamic and is developmentally regulated. SEQUENCE SIMILARITIES: Belongs to the neuropilin family. Contains 2 CUB domains. Contains 2 F5/8 type C domains. Contains 1 MAM domain. |
| Molecular Weight | 130 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot in mouse P1 brain tissue lysate. Western Blot Analysis: 1:1000 dilution of this antibody detected Neuropilin-2 on 10 µg of mouse P1 brain tissue lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |