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LIM homeobox 2, also known as LHX2, is a gene that belongs to the LIM homeobox family. These genes seem to play an important role in asymmetric cell division, tissue specification and differentiation of specific cell types. LHX2 is expressed in developing B-cells, the forebrain, liver, during embryonic development when limbs and organs are developing, in the optic stalk, and olfactory epithelia. Studies have shown that under-expression of LHX2 during embryonic development causes hepatic fibrosis.
Product Information
Format
Affinity Purified
Control
Human hippocampal and mouse cerebellum tissue.
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Lhx2 Antibody is validated for use in IH for the detection of Lhx2.
Key Applications
Immunohistochemistry
Biological Information
Immunogen
This antibody is generated from rabbits immunized with a KLH conjugated linear peptide selected from residues of human LHX2.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody recognizes LHX2.
Species Reactivity
Human
Species Reactivity Note
Demonstrated to react with human. Expected to react with horse, dog, and cow (93%) homology. Mouse (80%) homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_004780.1
Gene Symbol
LH-2
LH2
MGC138390
OTTHUMP00000022092
hLhx2
Purification Method
Affinity Purfied
UniProt Number
P50458
UniProt Summary
FUNCTION: Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types By similarity. SUBCELLULAR LOCATION: Nucleus Probable. SEQUENCE SIMILARITIES: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains.
Molecular Weight
Approx. 44 kDa
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human hippocampal and mouse cerebellum tissue. Immunohistochemistry Analysis: 1:100-500 dilution of this lot detected LHX2 in human hippocampal tissue and mouse cerebellum.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain refrigerated at 2-8°C for up to 12 months.
