Cell Signaling Gsk-3beta (D5c5z) Xp Rabbit mAb (Pe Conjugate)

Name: Cell Signaling Gsk-3beta (D5c5z) Xp Rabbit mAb (Pe Conjugate)
SKU: CSIG-72115S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Gsk-3beta (D5c5z) Xp Rabbit mAb (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-72115S

MFG.PART: 72115S

UNSPSC: 41116113

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M R Mk
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.
Specificity/Sensitivity	GSK-3β (D5C5Z) XP® Rabbit mAb (PE Conjugate) recognizes endogenous levels of total GSK-3β protein. This antibody does not cross-react with GSK-3α protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human GSK-3β protein.
Background	Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).

Specifications