Revvity Htrf Human Total Kras Detection Kit, 500 Assay Points

Revvity The htrf total kras cellular assay monitors total kras, a member of the ras sub family, and is used to detect the expression of endogenous wild-type as well as mutated kras in various cellular models. Kras g12d, kras g12c, and kras g12v are mutated oncogenic forms of kras that play a role in several cancers such as lung, colorectal, or pancreatic cancers. When kras is mutated, the g protein activation cycle is maintained in the "on" state leading to constitutive activation of downstream signaling pathways, such as mapkinase, which in turn lead to cancer progression. - PEGSK (Additional S&H Or Hazmat Fees May Apply)