Revvity Cereblon binding kit, 100000 Tests

Revvity A fast and easy way to identify new binders to Cereblon WT protein. Cereblon, also known as CRBN, is involved in many biological processes and is closely associated with proliferation, apoptosis, cell metabolism, and the occurrence of many diseases. Cereblon is also one of the two most popular E3 ligases which is recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein. Cereblon interacts with several proteins to form the functional E3 ubiquitin ligase complex, in which CRBN functions as a substrate receptor of the E3 ubiquitin ligase complex and targets proteins for proteolysis. Identifying new Cereblon ligands is therefore a way to control biological processes involved in oncology, neurodegenerative, or metabolic diseases by inducing the proteasomal-dependent degradation of undesired proteins. - PEMSD (Additional S&H or Hazmat Fees May Apply)