Revvity HTRF Human VHL Binding Kit, 100000 Tests

Revvity A fast and easy way to identify new binders to VHL protein. VHL, also known as von Hippel-Lindau, is involved in many biological processes and is closely associated with the regulation of angiogenesis, cell growth, or cell survival. VHL is one of the most popular E3 ligases recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein. VHL interacts with several proteins to form the functional von Hippel-Lindau ubiquitination complex, in which VHL seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex, and targets various proteins to proteolysis such as the hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Therefore, identifying new PROTAC VHL ligands can improve selective proteasomal-dependent degradation of proteins of interest, involved in the onset of diseases such as cancers. - PEMSD