Revvity HTRF Human and Mouse Total CK1a Detection Kit, 500 Assay Points

Casein kinase 1 (CK1) is a Serine/Threonine kinase that is ubiquitously expressed in eukaryotic organisms. Among its seven isoforms, CK1 alpha is involved in a wide range of cellular processes, including membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, differentiation, circadian rhythm, the immune response, neurodegeneration, and cancer.

CELMoDs (Cereblon E3 Ligase Modulating Drugs), derived from IMIDs (immunomodulatory imide drugs), represent a promising therapeutic approach in cancer treatment, particularly in hematological malignancies, due to their mechanism as molecular glues. Notably, some CELMoDs, such as Iberdomide and CC-92480, specifically target CK1A by promoting its ubiquitination and degradation, thereby inhibiting cancer cell growth and proliferation.