Revvity HTRF Human Total KRAS Detection Kit, 500 Assay Points

KRAS is a monomeric GTPases that relays signals from receptor tyrosine kinases promoting cell proliferation, differentiation or survival. KRAS is one of the most frequently mutated oncogenes in cancer. Mutation is commonly associated with poor prognosis and resistance to therapy. The KRAS G12C mutation is one of the more common KRAS mutations. KRAS G12C is constitutively active, in a persistently GTP-bound state, resulting in overstimulation of the KRAS effector signaling MAPK pathways and driving tumor growth.