Revvity Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic A

Revvity 250 µCi quantities of Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-³H]-, are available for your research. AMPA acts as an agonist at the AMPA receptor. This receptor is a ligand-gated ion channel and potential drug target for neurological diseases including epilepsy, migraine, and Alzheimers disease. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity References for NET833: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Kärkkäinen, O., Kupila, J., Häkkinen, M., Laukkanen, V., Tupala, E., Kautiainen, H., Tiihonen, J., Storvik, M. (2013) AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study, Psychiatry Research: Neuroimaging, 214 (3): 429-434.Mutel, V., Trube, g., Klingelschmidt, A., Messer, J., Bleuel, Z., Humbel, U., Clifford, M. M., Ellis, g. J. and Richards, J. g. (1998), Binding Characteristics of a Potent AMPA Receptor Antagonist [3H]Ro 48-8587 in Rat Brain. Journal of Neurochemistry, 71: 418–426.