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Revvity Ditolylguanidine acts as an agonist at sigma receptors (σ1 and σ2), and has neuroprotective and antidepressant effects. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

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Revvity References for NET986: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Dhwanil A. Dalwadi, Seongcheol Kim, John A. Schetz, Activation of the sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astroglia, In Neurochemistry International, Volume 105, 2017, Pages 21-31.Diaz, J. L.; Christmann, U.; Fernandez, A.; Torrens, A.; Port, A.; Pascual, R.; Alvarez, I.; Burgueno, J.; Monroy, X.; Montero, A. Synthesis and Structure-Activity Relationship Study of a New Series of Selective σ1 Receptor Ligands for the Treatment of Pain: 4-Aminotriazoles J. Med. Chem. 2015, 58, Pages 2441– 2451.