Revvity HTRF Human Total JAK2 Detection Kit, 50,000 Assay Points

Revvity JAK2 (Janus kinase 2) belongs to the family of non-receptor Janus tyrosine kinases with JAK1, JAK3, and TYK2. A wide array of cytokines and growth factors ( IL6, IL4, IFN alpha, GM-CSF) attached to their receptors induce the phosphorylation of JAKs. The activated JAKs subsequently phosphorylate additional targets, including both the cytokine receptors and the major substrates: STATs. The JAKs/SATs signaling stimulates cell proliferation, differentiation, migration, and apoptosis. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)