Revvity HTRF Human and Mouse Total CK1a Detection Kit, 50,000 Assay Points

Revvity Casein kinase 1 (CK1) is a Serine/Threonine kinase that is ubiquitously expressed in eukaryotic organisms. Among its seven isoforms, CK1 alpha is involved in a wide range of cellular processes, including membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, differentiation, circadian rhythm, the immune response, neurodegeneration, and cancer. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity CELMoDs (Cereblon E3 Ligase Modulating Drugs), derived from IMIDs (immunomodulatory imide drugs), represent a promising therapeutic approach in cancer treatment, particularly in hematological malignancies, due to their mechanism as molecular glues. Notably, some CELMoDs, such as Iberdomide and CC-92480, specifically target CK1A by promoting its ubiquitination and degradation, thereby inhibiting cancer cell growth and proliferation. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)