Revvity Cgp 39653, -, 1mci (37mbq)

Revvity CGP 39653 (D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentenoic acid) inhibits the binding of glutatmate to NMDA receptors and binds to rat frontal cortical membranes in a saturable and reversible manner. NMDA receptors are glutamate receptors involved in synaptic plasticity and memory function, and are targets for legal and illicit anesthetic drugs. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity References for NET1050: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Kawakami, Z., Ikarashi, Y. & Kase, Y. Isoliquiritigenin is a Novel NMDA Receptor Antagonist in Kampo Medicine Yokukansan. Cell Mol Neurobiol (2011) 31: 1203.Mugnaini, M., Giberti, A., Ratti, E. and van Amsterdam, F. Th. M. (1993), Allosteric Modulation of [3H]CGP 39653 Binding by Glycine in Rat Brain. Journal of Neurochemistry, 61: 1492–1497