Revvity (-)-Cgp-12177, -, 250µci (9.25mbq)

Revvity (-)-CGP-12177 is a high affinity antagonist of both β1- and β2-adrenoceptors, and functions as a partial agonist at β3-adrenoceptors. These receptors are part of a group of beta adrenergic g-protein coupled receptors (GPCRs) found in adipose tissue, heart tissue, and vascular smooth muscle tissue that play a role in cardiac output, hormone release, smooth muscle relaxation, and lipolysis. Beta adrenergic receptors have been identified as potential drug targets for congestive heart failure, hypertension, asthma, COPD, and neoplasia. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Revvity References for NET1061: - REVPFZ (Additional S&H Or Hazmat Fees May Apply)

Mark Soave, Gabriella Cseke, Catherine J. Hutchings, Alastair J.H. Brown, Jeanette Woolard, Stephen J. Hill, A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines, In Biochemical Pharmacology, Volume 147, 2018, Pages 38-54.Jan-Peter van Wieringen, Martina B. Michel-Reher, Toshiki Hatanaka, Koji Ueshima, Martin C. Michel, The new radioligand [3H]-L 748,337 differentially labels human and rat β3-adrenoceptors, In European Journal of Pharmacology, Volume 720, Issues 1–3, 2013, Pages 124-130.Violaine Simon, Marie-Thérèse Robin, Chantal Legrand, Joëlle Cohen-Tannoudji; Endogenous g Protein-Coupled Receptor Kinase 6 Triggers Homologous β-Adrenergic Receptor Desensitization in Primary Uterine Smooth Muscle Cells, Endocrinology, Volume 144, Issue 7, 1 July 2003, Pages 3058–3066.